677 research outputs found
High sensitivity phonon-mediated kinetic inductance detector with combined amplitude and phase read-out
The development of wide-area cryogenic light detectors with good energy
resolution is one of the priorities of next generation bolometric experiments
searching for rare interactions, as the simultaneous read-out of the light and
heat signals enables background suppression through particle identification.
Among the proposed technological approaches for the phonon sensor, the
naturally-multiplexed Kinetic Inductance Detectors (KIDs) stand out for their
excellent intrinsic energy resolution and reproducibility. To satisfy the large
surface requirement (several cm) KIDs are deposited on an insulating
substrate that converts the impinging photons into phonons. A fraction of
phonons is absorbed by the KID, producing a signal proportional to the energy
of the original photons. The potential of this technique was proved by the
CALDER project, that reached a baseline resolution of 1547 eV RMS by
sampling a 22 cm Silicon substrate with 4 Aluminum KIDs. In this
paper we present a prototype of Aluminum KID with improved geometry and quality
factor. The design improvement, as well as the combined analysis of amplitude
and phase signals, allowed to reach a baseline resolution of 824 eV by
sampling the same substrate with a single Aluminum KID
Necroptosis in intestinal inflammation and cancer: new concepts and therapeutic perspectives
Necroptosis is a caspases-independent programmed cell death displaying intermediate features between necrosis and apoptosis. Albeit some physiological roles during embryonic development such tissue homeostasis and innate immune response are documented, necroptosis is mainly considered a pro-inflammatory cell death. Key actors of necroptosis are the receptor-interacting-protein-kinases, RIPK1 and RIPK3, and their target, the mixed-lineage-kinase-domain-like protein, MLKL. The intestinal epithelium has one of the highest rates of cellular turnover in a process that is tightly regulated. Altered necroptosis at the intestinal epithelium leads to uncontrolled microbial translocation and deleterious inflammation. Indeed, necroptosis plays a role in many disease conditions and inhibiting necroptosis is currently considered a promising therapeutic strategy. In this review, we focus on the molecular mechanisms of necroptosis as well as its involvement in human diseases. We also discuss the present developing therapies that target necroptosis machinery
Krill oil, vitamin D and Lactobacillus reuteri cooperate to reduce gut inflammation
Current research into original therapies to treat intestinal inflammation is focusing on no-drug therapies. KLD is a mixture of krill oil (KO), probiotic Lactobacillus reuteri (LR), and vitamin D (VitD3). The aim of this study was to assess in vitro and in vivo the potential cooperative effects of KLD in reducing gut inflammation. Colorectal adenocarcinoma cell lines, CACO2 and HT29, and C57BL/6 mice were used for in vitro and in vivo analyses, respectively. Cells were exposed to cytomix (interferon gamma + tumour necrosis factor alpha (TNF-a)) to induce inflammation or co-exposed to cytomix and KO, LR and VitD3 alone or to cytomix and KLD. Animals were treated for 7 days with dextran sodium sulphate (DSS) to induce colitis or with DSS and KLD. In vitro assays: F-actin expression was analysed by immunofluorescence; scratch test and trans-epithelial electric resistance test were performed to measure wound healing; adhesion/invasion assays of adhesive and invasive Escherichia coli (AIEC) bacteria were made; mRNA expression of TNF-α, interleukin (IL)-8 and vitamin D receptor (VDR) was detected by quantitative PCR. In vivo assays: body weight, clinical score, histological score and large intestine weight and length were estimated; mRNA expression of TNF-α, IL-1ß, IL-6, IL-10 by quantitative PCR; VDR expression was detected by quantitative PCR and immunohistochemistry. In vitro: KLD restores epithelial cell-cell adhesion and mucosal healing during inflammation, while decreases the adhesiveness and invasiveness of AIEC bacteria and TNF-α and IL-8 mRNA expression and increases VDR expression. In vivo: KLD significantly improves body weight, clinical score, histological score and large intestine length of mice with DSS-induced colitis and reduces TNF-α, IL-1ß and IL-6 mRNA levels, while increases IL-10 mRNA and VDR levels. KLD has significant effects on the intestinal mucosa, strongly decreasing inflammation, increasing epithelial restitution and reducing pathogenicity of harmful commensal bacteria
Land use planning for utilizing biomass residues in Tuscia Romana (central Italy) : preliminary results of a multi criteria analysis to create an agro-energy district
This study provides a preliminary agro-environmental, economic and energetic analysis to critically evaluate the biomass potential of an area of central Italy (Tuscia Romana). This area is selected as representative for agro-forestry from its orographic characteristics, climatic conditions, land use and potential energy sources. Accordingly, the model we have obtained could be used for other similar areas of central Italy. We have assessed the potential agro-forestry biomass availability, energy po-tential and transport infrastructure using multi criteria analysis and geographic information system approaches. Finally, optimum locations to develop an energy plant were identified. This model could be applied at a local level to help deliver environmental policy
Energy Characterization and Gasification of Biomass Derived by Hazelnut Cultivation: Analysis of Produced Syngas by Gas Chromatography
Modern agriculture is an extremely energy intensive process. However, high agricultural productivities and the growth of green revolution has been possible only by large amount of energy inputs, especially those coming from fossil fuels. These energy resources have not been able to provide an economically viable solution for agricultural applications. Biomass energy-based systems had been extensively used for transportation and on farm systems during World War II: the most common and reliable solution was wood or biomass gasification. The latter means incomplete combustion of biomass resulting in production of combustible gases which mostly consist of carbon monoxide (CO), hydrogen (H2) and traces of methane (CH4). This mixture is called syngas, which can be successfully used to run internal combustion engines (both compression and spark ignition) or as substitute for furnace oil in direct heat applications. The aim of the present paper is to help the experimentation of innovative plants for electric power production using agro-forest biomass derived by hazelnut cultivations. An additional purpose is to point out a connection among the chemical and physical properties of the outgoing syngas by biomass characterization and gas-chromatography analysis
Characterization of the KID-Based Light Detectors of CALDER
The aim of the Cryogenic wide-Area Light Detectors with Excellent Resolution
(CALDER) project is the development of light detectors with active area of
cm and noise energy resolution smaller than 20 eV RMS,
implementing phonon-mediated kinetic inductance detectors. The detectors are
developed to improve the background suppression in large-mass bolometric
experiments such as CUORE, via the double read-out of the light and the heat
released by particles interacting in the bolometers. In this work, we present
the characterization of the first light detectors developed by CALDER. We
describe the analysis tools to evaluate the resonator parameters (resonant
frequency and quality factors) taking into account simultaneously all the
resonance distortions introduced by the read-out chain (as the feed-line
impedance and its mismatch) and by the power stored in the resonator itself. We
detail the method for the selection of the optimal point for the detector
operation (maximizing the signal-to-noise ratio). Finally, we present the
response of the detector to optical pulses in the energy range of 0-30 keV
New application of superconductors: high sensitivity cryogenic light detectors
In this paper we describe the current status of the CALDER project, which is
developing ultra-sensitive light detectors based on superconductors for
cryogenic applications. When we apply an AC current to a superconductor, the
Cooper pairs oscillate and acquire kinetic inductance, that can be measured by
inserting the superconductor in a LC circuit with high merit factor.
Interactions in the superconductor can break the Cooper pairs, causing sizable
variations in the kinetic inductance and, thus, in the response of the LC
circuit. The continuous monitoring of the amplitude and frequency modulation
allows to reconstruct the incident energy with excellent sensitivity. This
concept is at the basis of Kinetic Inductance Detectors (KIDs), that are
characterized by natural aptitude to multiplexed read-out (several sensors can
be tuned to different resonant frequencies and coupled to the same line),
resolution of few eV, stable behavior over a wide temperature range, and ease
in fabrication. We present the results obtained by the CALDER collaboration
with 2x2 cm2 substrates sampled by 1 or 4 Aluminum KIDs. We show that the
performances of the first prototypes are already competitive with those of
other commonly used light detectors, and we discuss the strategies for a
further improvement
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